Formulation and Evaluation of Floating Tablets of Cimetidine
نویسندگان
چکیده
منابع مشابه
Floating microspheres of cimetidine: formulation, characterization and in vitro evaluation.
The present study involves preparation and evaluation of floating microspheres with cimetidine as model drug for prolongation of gastric residence time. The microspheres were prepared by the solvent evaporation method using polymers hydroxypropylmethyl cellulose and ethyl cellulose. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron mic...
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The low bioavailability (15%) and good solubility of Domperidone Maleate in acidic pH following oral administration favours development of a gastro retentive formulation. Gastroretentive floating matrix tablets of Domperidone Maleate were successfully prepared with hydrophilic polymers like HPMC K4M, HPMC K15M and HPMC K100M. From the Preformulation studies for drug excipients compatibility it ...
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Tizanidine hydrochloride is an orally administered prokinetic agent that facilitates or restores motility through-out the length of the gastrointestinal tract. The objective of the present investigation was to develop effervescent floating matrix tablets of tizanidine hydrochloride for prolongation of gastric residence time in order to overcome its low bioavailability (34-40 %) and short biolog...
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Nateglinide is a novel, highly physiologic, glucose regulator recently approved for the treatment of type-2 diabetes mellitus. Nateglinide has a rapid onset and short duration of insulinotropic action that results in reduction of glucose level. The purpose of this study to develop a floating tablet of Nateglinide to enhance its bioavailability and sustained action. In the present study a 32 ful...
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The importance of the present investigation was to formulate a bilayer-floating tablet (BFT) for captopril using direct compression technology. The release layer contained captopril and various polymers such as HPMC-K15M, PVP-K30 and Carbopol 934p, alone or in combination with the drug. HPMC, K-grade and effervescent mixture of citric acid and sodium bicarbonate formed the floating layer. The f...
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ژورنال
عنوان ژورنال: International Journal of ChemTech Research
سال: 2018
ISSN: 0974-4290,2455-9555
DOI: 10.20902/ijctr.2018.110944